WAP, kazal, immunoglobulin, kunitz & NTR domain-containing protein 1; growth & differentiation factor-associated serum protein 2; WAP, follistatin, immunoglobulin, Kunitz & NTR domain-containing protein (GASP-2, hGASP-2, WFIKKN1, GASP2, WFIKKN, PSEC0040)

Function

• protease-inhibitor
• contains multiple distinct protease inhibitor domains
• probably has serine protease inhibitor & metalloprotease-inhibitor activity
• biomarker of brain aging (negative correlation)

Structure

• belongs to the WFIKKN family
• contains 2 BPTI/Kunitz inhibitor domains
  • 2nd BPTI/Kunitz inhibitor domain is able to inhibit trypsin
    • it has no activity toward chymotrypsin, elastase, plasmin, pancreatic kallikrein, lung tryptase, plasma kallikrein, thrombin, urokinase or tissue plasminogen activator
• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 Kazal-like domain
• contains 1 NTR domain
• contains 1 WAP domain

Compartment

• secreted (putative)

Expression

• expressed in pancreas, kidney, liver, placenta, & lung

More general terms

• secreted protein

Database

• OMIM: https://mirror.omim.org/entry/608021
• UniProt: http://www.uniprot.org/uniprot/Q96NZ8.html