ophthalmoplegia (ophthalmoparesis)

Introduction

Paralysis of one or more of the extra-ocular muscles.

Etiology

• thiamine deficiency
• temporal arteritis
• progressive supranuclear palsy
• lacunar infarct
• pituitary apoplexy
• orbital cellulitis (painful)
• periorbital edema (painful)
• cavernous sinus thrombosis (painful)
• internuclear ophthalmoplegia
  • multiple sclerosis
  • drug adverse effects of checkpoint inhibitor(s)
• progressive external ophthalmoplegia
• hyperthyroidism
• intestinal lipodystrophy (Whipple's disease)
• Miller-Fisher syndrome
• progressive bulbar paralysis (Duchenne syndrome)
• Nonaka distal myopathy
• myasthenic syndrome
  • myasthenia gravis
• genetic disorders
  • mitochondrial myopathy

Diagnostic procedures

• biopsy, extraocular muscle

More general terms

• sign/symptom
• eye disease (ophthalmopathy)

More specific terms

• chronic progressive external ophthalmoplegia (CPEO)
• external ophthalmoplegia; progressive external ophthalmoplegia (PEO)
• internuclear ophthalmoplegia (INO)

Additional terms

• twinkle protein, mitochondrial; T7 gp4-like protein with intramitochondrial nucleoid localization; T7-like mitochondrial DNA helicase; Progressive external ophthalmoplegia 1 protein (PEO1, C10orf2)