Dupuytren contracture

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Introduction

A disorder of the palmar fascia characterized by flexion deformity of the 4th & 5th digits.

Epidemiology

  • most common age 40-60
  • male:female ratio 10:1
  • Scandanavians & northern Europeans

Pathology

Clinical manifestations

Complications

Differential diagnosis

Management

* surgery more successful than collagenase injections or needle fasciotomy (78% vs 65%)[4]

More general terms

References

  1. Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999.
  2. Ferri's Clinical Advisor, Instant Diagnosis and Treatment, Ferri FF (ed), Mosby, Philadelphia, 2003
  3. Hurst LC et al, Injectable Collagenase Clostridium Histolyticum for Dupuytren's Contracture N Engl J Med 2009, 361:968-979 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19726771 <Internet> http://content.nejm.org/cgi/content/short/361/10/968
  4. 4.0 4.1 Raisanen MP et al. Surgery, needle fasciotomy, or collagenase injection for Dupuytren contracture: A randomized controlled trial. Ann Intern Med 2024 Feb 13; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38346307 https://www.acpjournals.org/doi/10.7326/M23-1485
  5. 5.0 5.1 International Dupuytren Society Techniques of hand surgery http://www.dupuytren-online.info/dupuytren_surgery_techniques.html
  6. 6.0 6.1 Dias J, Tharmanathan P, Arundel C et al. Collagenase injection versus limited fasciectomy for Dupuytren's contracture. N Engl J Med 2024 Oct 9:10.1056/NEJMoa2312631 PMID: https://www.ncbi.nlm.nih.gov/pubmed/39383454 PMCID: PMC7616701 Free PMC article. https://www.nejm.org/doi/10.1056/NEJMoa2312631