complex regional pain syndrome
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Classification
- type 1: reflex sympathetic dystrophy
- no observable nerve lesions
- type 2: causalgia
- observable nerve lesions
Pathology
Clinical manifestations
- severe pain, swelling, & changes in the skin
- often affects an arm or a leg
- may spread to another part of the body
Management
- clinical guidelines recommend bisphosphonates despite limited evidence of efficacy
- bisphosphonates may reduce pain intensity in the short term, but treatment is accompanied by adverse events[5]
More general terms
More specific terms
- causalgia; complex regional pain syndrome type 2
- complex regional pain syndrome type 1; reflex sympathetic dystrophy; RSD; hand shoulder syndrome; algodystrophy; algoneurodystrophy; Sudeck's atrophy; reflex neurovascular dystrophy
References
- ↑ Wikipedia: Complex regional pain syndrome http://en.wikipedia.org/wiki/Complex_regional_pain_syndrome
- ↑ Bussa M et al. Complex regional pain syndrome type I: A comprehensive review. Acta Anaesthesiol Scand 2015 Jul; 59:685. PMID: https://pubmed.ncbi.nlm.nih.gov/25903457
- ↑ Freedman M et al. Complex regional pain syndrome: Diagnosis and treatment. Phys Med Rehabil Clin N Am 2014 May; 25:291. PMID: https://pubmed.ncbi.nlm.nih.gov/24787334
- ↑ NEJM Knowledge+ Question of the Week. Aug 11, 2020 https://knowledgeplus.nejm.org/question-of-week/756/
- ↑ 5.0 5.1 Ferraro MC, O'Connell NE, Goebel A et al Efficacy and Safety of Bisphosphonates for Complex Regional Pain Syndrome : A Systematic Review and Meta-analysis. Ann Intern Med. 2025 Dec 16. PMID: https://pubmed.ncbi.nlm.nih.gov/41397259 Review. https://www.acpjournals.org/doi/10.7326/ANNALS-25-03693