Pennsylvania smell identification scale (UPSIT)
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Introduction
A 40 odor discrimination test.
Self-administered scratch-&-sniff test.
A 10 odor test (subset of 40) predicts development of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI).[1]
A 12 odor test (subset of 40): poor performance on odor identification testing correlated with measures of amyloid plaques* & neurofibrillary tangles.[2]
* seems inconsistent with Braak staging
- leather, clove, menthol, strawberry, pineapple, natural gas, lemon, lilac, soap, smoke
Impairment of odor discrimation is early event in AD.
One of 5 strong predictors of developing Alzheimer's disease in patients with mild cognitive impairment (MCI).
Additional terms
References
- ↑ 1.0 1.1 Tabert MH et al, A 10-item smell identification scale related to risk for Alzheimer's disease Ann Neurol 2005 July;58:155-60 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15984022
- ↑ 2.0 2.1 Wilson RS, Arnold SE, Schneider JA, Tang Y, Bennett DA. The relationship between cerebral Alzheimer's disease pathology and odour identification in old age. J Neurol Neurosurg Psychiatry. 2007 Jan;78(1):30-5. Epub 2006 Sep 29. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17012338
- ↑ Growdon ME et al. Odor identification and Alzheimer disease biomarkers in clinically normal elderly. Neurology 2015 May 26; 84:2153. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25934852
Devanand DP et al. Olfactory identification deficits and increased mortality in the community. Ann Neurol 2015 Jun 1; PMID: https://www.ncbi.nlm.nih.gov/pubmed/26031760