menthol (Biofreeze)
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Introduction
A terpene alcohol obtained from peppermint oil or synthesized from inorganic compounds.
Uses
- antipruritic agent
- topical anesthetic
- topical agent for upper respiratory tract infection
- along with menthol & eucalyptus oil, component of Vicks Vaporub
- in nasal spraysm cough drops & inhalers
- as a flavoring agent
Adverse effects
- although menthol is preceived as increased airflow across the nostrils, nasal airflow resistance is acutally increased within a minute of menthol application & this effect persists for > 3 hours
- inhalation of menthol may result in aspiration, apnea, laryngoconstriction, nausea, ataxia, confusion, euphoria
Mechanism of action
- binds to a receptor causing intracellular influx of Ca+2
- responsible for the feeling of congestion relief in Vicks VapoRub
More general terms
Component of
- menthol/witch hazel
- menthol/salicylate
- menthol/petrolatum
- menthol/panthenol/salicylic acid
- mannitol/menthol
- lanolin/menthol/petrolatum/zinc oxide
- histamine/menthol/methyl salicylate
- h2o2/menthol
- eucalyptol/menthol/sodium fluoride/thymol
- coal tar/menthol/shampoo
- coal tar/menthol/salicylic acid/shampoo
- camphor/menthol/nh3
- camphor/lidocaine/menthol/methyl salicylate
- camphor/eugenol/menthol
- camphor/eucalyptus oil/menthol/peppermint oil
- camphor/dimethicone/lidocaine/menthol
- calamine/lanolin/menthol/zinc oxide
- benzocaine/menthol/zinc chloride
- benzocaine/isopropanol/menthol
- benzalkonium/menthol
- ascorbate/menthol
- allantoin/camphor/menthol
- allantoin/benzocaine/camphor/dimethicone/menthol/petrolatum
- activon/histamine/menthol
- menthol/zinc/zinc oxide
- menthol/white petrolatum
- menthol/sodium fluoride/thymol
- menthol/sodium chloride
- menthol/pramoxine/white petrolatum
- menthol/pectin
- menthol/methyl salicylate/thymol
- lidocaine/menthol/methyl salicylate
- lidocaine/menthol
- lanolin/menthol/zinc oxide
- hexylresorcinol/menthol
- eucalyptol/menthol/methyl salicylate/thymol
- ethanol/menthol
- dyclonine/menthol/pectin
- dyclonine/menthol
- diphenhydramine/menthol
- dimethicone/menthol
- dextromethorphan/menthol
- cortisol/hexachlorophene/menthol
- coal tar/menthol/salicylic acid
- coal tar/menthol
- chloroxylenol/iodine/menthol
- capsaicin/menthol/methyl salicylate
- capsaicin/lidocaine/menthol/methyl salicylate
- camphor/menthol/white petrolatum
- camphor/menthol/phenol
- camphor/eucalyptus oil/menthol/methyl salicylate
- camphor/dimethicone/menthol/phenol
- camphor/capsicum/menthol
- camphor/capsaicin/menthol/methyl salicylate/peppermint oil/zinc oxide
- camphor/capsaicin/menthol/methyl salicylate
- camphor/capsaicin/menthol
- calamine/menthol/zinc oxide
- calamine/menthol/white petrolatum/zinc oxide
- benzyl alcohol/menthol
- benzyl alcohol/camphor/menthol/zinc acetate
- benzyl alcohol/camphor/menthol
- benzocaine/menthol/methyl salicylate
- benzocaine/dextromethorphan/menthol
- benzocaine/cetylpyridinium/menthol/zinc chloride
- benzocaine/cetylpyridinium/menthol (Cepacol)
- benzethonium/benzocaine/menthol
- benzalkonium/menthol/white petrolatum
- aspirin/camphor/menthol/methyl salicylate
- alpha tocopherol/menthol
- allantoin/camphor/menthol/phenol
- allantoin/camphor/hexylresorcinol/menthol
- camphor/eucalyptus/menthol
- menthol/pramoxine
- menthol/methyl salicylate
- menthol/zinc oxide
- menthol/phenol
- histamine/menthol
- capsaicin/menthol
- camphor/menthol/methyl salicylate
- camphor/menthol
- benzocaine/menthol
References
- ↑ Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999.
- ↑ Prescriber's Letter 16(3): 2009 Vicks VapoRub Safety and Children Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=250322&pb=PRL (subscription needed) http://www.prescribersletter.com