trilisate (choline magnesium trisalicylate)

Introduction

Salicylate combination.

Indications

• osteoarthritis
• rheumatoid arthritis
• analgesic for mild to moderate pain

Contraindications

Caution:

• avoid use in patients with suspected varicella or influenza, especially in children; cases of Reye's syndrome have occurred

pregnancy-category C)

safety in lactation ?

Dosage

• adults:
  • 1 tab PO every 4-8 hours
  • 750 mg PO every 8 hours
  • 1.5 g PO every 12 hours
• children: 30-60 mg/kg//day divided TID-QID

Tabs: 500, 750, 1000 mg.

Liquid: 500 mg/5 mL

Pharmacokinetics

elimination: kidney

Adverse effects

• common (> 10%)
  • nausea, heartburn, stomach pains, dyspepsia, epigastric discomfort
• less common (1-10%)
  • weakness, tiredness, hemolytic anemia, skin rash, dyspnea, gastrointestinal ulceration, anaphylactic shock
• uncommon (< 1%)
  • insomnia, nervousness, 'jitters', occult bleeding, prolongation of bleeding time, leukopenia, thrombocytopenia, hepatotoxicity, bronchospasm, iron-deficiency anemia, impaired renal function

Drug interactions

• may enhance hypothrombinemic effects of warfarin
• may increase methotrexate serum levels & toxicity

• drug interaction(s) of beta-adrenergic receptor antagonists with salicylate
• drug interaction(s) of salicylates with sulfonylureas

More general terms

• pharmacologic combination

Components

• salicylate
• choline
• Mg+2

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=47361