ophthalmic (choroidal/uveal/orbital) lymphoid hyperplasia
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Introduction
- proliferation of nonmalignant lymphocytes in the uveal tract, conjunctiva, eyelid, or orbit
Etiology
- case associated with dulaglutide
Epidemiology
- rare
Clinical manifestations
- monocular painless vision loss
Diagnostic procedures
- ophthalmoscopy
- creamy-orange choroidal infiltrates distributed in a peripapillary & macular pattern with undulating choroid (choroidal folds) & overlying orange pigment & subretinal fluid
- lymph node biopsy
Radiology
Complications
- can occasionally evolve into low-grade lymphoid neoplasm
Management
- resolution with discontinuation of dulaglutide
More general terms
References
- ↑ Bankhead C GLP-1 Drug Linked to Cases of Rare Vision-Altering Condition. Resolution occurred after stopping dulaglutide, no obvious clues to mechanism. MedPage Today. May 13, 2026
Francis JH, Mendelsohn RB, Canestraro J, et al Dulaglutide-Associated Choroidal Lymphoid Hyperplasia. N Engl J Med. 2026 May 14;394(19):1959-1961. doi:http://dx.doi.org/ 10.1056/NEJMc2600397. PMID: https://pubmed.ncbi.nlm.nih.gov/42127399 https://www.nejm.org/doi/full/10.1056/NEJMc2600397 - ↑ Andrew NH, Sladden N, Kearney DJ, Selva D. Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical pathologic review. Surv Ophthalmol. 2016 Nov-Dec;61(6):778-790 PMID: https://pubmed.ncbi.nlm.nih.gov/27127077 Review.