mild autonomous cortisol secretion

Etiology

• adrenal incidentalomas without clinically obvious Cushing syndrome

Clinical manifestations

• as likely as patients with Cushing syndrome to have comorbidities:
  • hypertension, diabetes mellitus, dyslipidemia, depression, osteoporosis
• features of Cushing syndrome not uncommon
  • weight gain (50%), dorsocervical fat pad (24%), facial plethora (23%)

Laboratory

• nonsuppressed serum cortisol > 1.9 ug/dL after overnight low-dose dexamethasone suppression test

Management

• adrenalectomy for unilateral cortisol secreting adrenal adenomas

More general terms

• adrenal gland disease