atrasentan (Vanrafia)

Indications

• treatment of proteinuria in IgA nephropathy*

* indicated for adults with urine protein/creatinine ratio of >= 1.5 g/g

Contraindications

• pregnancy, breast feeding

Dosage

• 0.75 mg once a day with or without food.

Adverse effects

• peripheral edema
• anemia*

* boxed warning about embryo-fetal toxicity

• drug adverse effects of antihypertensive agents

Mechanism of action

• selective endothelin A receptor antagonist

More general terms

• endothelin receptor antagonist

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=159594
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=159595