ataciguat
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Indications
- may slow progression of aortic stenosis & delay aortic valve replacement
Mechanism of action
- reactivation of oxidized soluble guanylate cyclase, the primary receptor for nitric oxide
- delays progression of aortic valve calcification
More general terms
References
- ↑ Zhang B, Enriquez-Sarano M, Schaff HV et al Reactivation of Oxidized Soluble Guanylate Cyclase as a Novel Treatment Strategy to Slow Progression of Calcific Aortic Valve Stenosis: Preclinical and Randomized Clinical Trials to Assess Safety and Efficacy. Circulation. 2025 Feb 24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39989354 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.066523