micropeptide inhibiting actin cytoskeleton (AQP5-AS1, MIAC)

Function

• reduces filamentous actin fibers by interacting with aquaporin AQP2 which leads to inhibition of the expression of SEPTIN4 & integrin ITGB4
• also inhibits the activation of the EREG/EGFR signaling pathway through interaction with AQP2
• interacts with aquaporin AQP2

Pathology

• inhibits head & neck squamous cell carcinoma (HNSCC) progression in vitro
• also inhibits renal cell carcinoma progression in vitro

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/A0A7L8Y648.html