epiregulin; contains: epiregulin; EPR (EREG)

Function

• may be a mediator of localized cell proliferation
• as a mitogen, it may stimulate cell proliferation &/or angiogenesis

Structure

contains 1 EGF-like domain

Compartment

• epiregulin: secreted, extracellular space
• proepiregulin: cell membrane

Expression

• in normal adults, expressed predominantly in placenta & peripheral blood leukocytes

Pathology

• high levels detected in serveral carcinomas
  • bladder carcinoma
  • lung carcinoma
  • renal cell carcinoma
  • colon carcinoma

More general terms

• membrane protein
• growth factor
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2069
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2069
• OMIM: https://mirror.omim.org/entry/602061
• UniProt: http://www.uniprot.org/uniprot/O14944.html