metal in urine
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Pathology
| Metal | RR of CVD | RR of death | RR of dementia |
|---|---|---|---|
| copper | 1.42 | 1.50 | 1.16 |
| zinc | 1.21 | 1.38 | 1.35 |
| cobalt | 1.24 | 1.37 | 1.18 |
| manganese | - | - | 1.00 |
| uranium | 1.32 | 1.32 | 1.46 |
| tungsten | 1.20 | 1.16 | 1.15 |
| arsenic | - | - | 1.32 |
| lead | - | - | 0.92 |
| cadmium | 1.25 | 1.68 | 1.17 |
* copper, zinc cobalt, manganese, uranium, tungsten, cadmium, arsenic, lead
* apoE4 allele may increase the relative risk of dementia[3]
More general terms
References
- ↑ Lou N These Metals in Urine Predict Heart Disease and Death. Exposure may come from food, water, and air MedPage Today, August 1, 2024 https://www.medpagetoday.com/cardiology/prevention/111319
Martinez-Morata I, Schilling K, Glabonjat RA et al Association of Urinary Metals With Cardiovascular Disease Incidence and All-Cause Mortality in the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2024. August 1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39087344 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.069414 - ↑ 2.0 2.1 McGraw KE, Schilling K, Glabonjat RA et al Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis (MESA). medRxiv [Preprint]. 2023 Nov 1:2023.10.31.23297878. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37961623 PMCID: PMC10635251 Free PMC article. Preprint.
McGraw KE, Schilling K, Glabonjat RA et al Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis. J Am Coll Cardiol. 2024 Sep 12:S0735-1097(24)07961-0 PMID: https://www.ncbi.nlm.nih.gov/pubmed/39297845 Free article. https://www.jacc.org/doi/10.1016/j.jacc.2024.07.020 - ↑ 3.0 3.1 George J Cognitive Performance Falls as Metal Exposure Rises. Carrying at least one copy of APOE4 may modify the association. MedPage Today December 3, 2024 https://www.medpagetoday.com/neurology/dementia/113199
Domingo-Relloso A, McGraw KE, Heckbert SR et al Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis. JAMA Netw Open. 2024;7(12):e2448286. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39621345 PMCID: PMC11612832 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2827187