Figure: oxidized tau-phosphate dimer with insert 3

Structure

• disulfide-linked dimers of hyperphosphorylated tau, linked through the microtubule binding domain, & oriented in an antiparallel fashion form paired helical filaments
• one of 2 configurations with 2 intermolecular disulfide bonds (C291 .. C291 & C322 .. C322)
• the Cys positions differ from those identified in the full-length protein presumbably due to splicing differences.