retatrutide

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Indications

* weight loss at 24 weeks 17% with 12 mg (effectiveness dose-dependent)

Dosage

  • start 2-4 mg
  • max 12 mg

Adverse effects

  • mostly GI, dose-related, partially mitigated by lower starting dose

Mechanism of action

More general terms

References

  1. Zoler ML Triple Agonist Retatrutide Hits New Weight-Loss Highs. Medscape. June 26, 2023 https://www.medscape.com/viewarticle/993714
    Jastreboff AM, Kaplan LM, Frias JP et al Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial. N Engl J Med. 2024. Jun 26. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37366315 https://www.nejm.org/doi/full/10.1056/NEJMoa2301972