glucagon receptor; GL-R (GCGR)

Function

• receptor for glucagon
• role in regulating blood glucose by controlling the rate of hepatic glucose production & insulin secretion
• activity is mediated by G proteins which activate adenylyl cyclase & also a phosphatidylinositol-Ca+2 second messenger system
• stimulates both cAMP & Ca+2 accumulation

Structure

belongs to the G-protein coupled receptor 2 family

Compartment

cell membrane; multi-pass membrane protein

Pathology

• candidate for defects in diabetes mellitus type-2 (NIDDM)
• Ser variant in position 40 is found in some type-2 diabetics, but also in non-diabetic subjects

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• glucagon; contains: glicentin; glicentin-related polypeptide; GRPP; oxyntomodulin; OXM; OXY; glucagon-like peptide 1; GLP-1; glucagon-like peptide 1(7-37); GLP-1(7-37); glucagon-like peptide 1(7-36); GLP-1(7-36); glucagon-like peptide 2; GLP-2 (GCG)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2642
• OMIM: https://mirror.omim.org/entry/138033
• UniProt: http://www.uniprot.org/uniprot/P47871.html