tapinarof; benvitimod, 3,5-dihydroxy-4-isopropylstilbene (VTMA)

Indications

• atopic dermatitis
• psoriasis

Dosage

• apply topically once daily

Cream 1%

Adverse effects

• folliculitis, nasopharyngitis, contact dermatitis, headache, pruritus, influenza

Mechanism of action

• aryl hydrocarbon receptor (AhR)-modulating agent
  • down-regulation of proinflammatory cytokines, including IL-17
  • regulates skin barrier protein expression
  • promotes skin barrier normalization

More general terms

• topical agent

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6439522