cognitive frailty
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Introduction
Reduced cognitive function in the absence of subjective memory complaints, or a clinical diagnosis of dementia.[1]
Etiology
- lower cognitive reserve, hearing impairment, & cardiovascular comorbidity might contribute to cognitive frailty.
Pathology
- proposed to be a precursor to Alzheimer's disease
- alternatively may represent separate process of inevitable cognitive aging
- cognitively frail have larger temporal gray matter volume, compared with people with mild cognitive impairment or Alzheimer's disease
- structural atrophy is absent
Clinical manifestations
- cognitive performance similar to adults with mild cognitive impairment
- neurophysiological signatures of Alzheimer's disease are absent
Differential diagnosis
- distinct from cognitive impairment caused by physical frailty
Management
- community-based multicomponent exercises may improve cognitive function & frailty status in elderly persons[2]
- for hospitalized elderly, nutritional support may be the most effective intervention to improve cognitive function[2]
- aerobic exercise & dual-task training may be of benefit[2]
More general terms
References
- ↑ 1.0 1.1 Kocagoncu E, Nesbitt D, Emery T et al Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's disease. Journal of Neuroscience 2022. January 10. https://www.jneurosci.org/content/early/2022/01/02/JNEUROSCI.0697-21.2021
- ↑ 2.0 2.1 2.2 2.3 Zhang Y, Zhou JJ, Zhang XM, et al. Management of cognitive frailty: A network meta-analysis of randomized controlled trials. Int J Geriatr Psychiatry. 2023 Sep;38(9):e5994. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37655500 https://journalwise.acponline.org/Articles/SpecialtyAlert/110599