cepharanthine
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Uses
- effective against HTLV in laboratory
- used in Japan since 1950s to treat radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia & various cancer-related conditions
* investigational use in combination with nelfinavir for treatment of Covid-19
Adverse effects
- rarely reported
Mechanism of action
- membrane effects
- modulation of efflux pumps
- membrane rigidification
- inhibits entry of SARS-CoV2 into cells by preventing the virus from binding to a protein on the cell membrane
- intracellular & nuclear effects
- interferes with AMP-activated protein kinase (AMPK) & NFkappaB signalling[2]
Notes
- isolated from the plant Stephania cephalantha Hayata
More general terms
- anti-inflammatory agent
- antioxidant
- antineoplastic agent (chemotherapeutic agent)
- antiviral agent
- antiparasitic agent
References
- ↑ Tokyo University of Science The dream team: Scientists find drug duo that may cure COVID-19 together. MedicalXpress. June 4, 2021 https://medicalxpress.com/news/2021-06-team-scientists-drug-duo-covid-.html
- ↑ 2.0 2.1 Bailly C Cepharanthine: An update of its mode of action, pharmacological properties and medical applications. Phytomedicine. 2019 Sep;62:152956 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31132753 PMCID: PMC7126782 Free PMC article