Alzheimer Disease Conversion-Related Pattern (ADCRP) Score

Indications

• may be useful in identifying those with mild cognitive impairment who have underlying Alzheimer disease (AD).

Procedure

• ADCRP scores were derived from two types of positron emission tomography.
  • 18F-FDG PET of temporoparietal an& precuneus/posterior cingulate activity
  • 18F-AV-45 amyloid PET
• computational modeling is used
• using CSF tau levels (T) & amyloid imaging (A), normal AD biomarkers were classified as A-T-, biologically defined AD as T+A+, AD pathologic change as A+T-, & non-AD pathologic change as A-T+
• persons with biologically defined AD had higher ADCRP scores than did those with other AT classifications
• CSF tau levels were increased in biologically defined AD participants but also in those with non-AD pathology
• plasma NfL levels were elevated only in those with AD pathologic changes
• MCI converters to AD dementia had higher ADCRP scores than MCI non-converters, & ADCRP scores had higher predictive value & better risk stratification for conversion to AD dementia than CSF tau & plasma NfL levels.

More general terms

• numerical rating scale (NRS)