voclosporin (Lupkynistm)

Indications

• for use in combination with an immunosuppressive therapy regimen to treat active lupus nephritis in adult

Adverse effects

• infections (10.1% vs 11.2%)
  • urinary tract infection (>3%)
• other > 3%
  • renal impairment
    • acute kidney injury
    • decrease in glomerular filtration rate
  • hypertension
  • anemia
  • cough
• abdominal pain, dyspepsia, diarrhea
• mouth ulceration
• decreased appetite
• fatigue
• tremor
• alopecia

• drug adverse effects of immunosuppressive agents
• drug adverse effects of calcineurin inhibitors

Mechanism of action

• calcineurin-inhibitor immunosuppressant

More general terms

• calcineurin inhibitor
• immunosuppressive agent