CD300H; CD300 antigen-like family member H (CD300H)

Function

• may play role in innate immunity by mediating a signal for production of a neutrophil chemoattractant
• interacts with TYROBP & HCST

Structure

belongs to the CD300 family,

Compartment

• [isoform 1]: membrane ; single-pass type I membrane protein
• [isoform 2]: secreted

Alternative splicing

named isoforms=2

Expression

• expressed on CD16+ monocytes & myeloid dendritic cells
• not expressed on lymphocytes or granulocytes

Polymorphism

• some individuals have a mutation (NM_001324073.1:c.61+1A>G) which abolishes the intron 1 donor splice site
  • persons carrying the A/A genotype shows a loss of CD300H transcripts & protein
  • the AA genotype occurs at high frequencies in East Asian & Northern/Western European populations, but is rare in West Africa

More general terms

• CD300 family protein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100130
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:100130
• OMIM: https://mirror.omim.org/entry/616560
• UniProt: http://www.uniprot.org/uniprot/A0A0K2S4Q6.html