protein myomixer; microprotein inducer of fusion; protein minion; hMINION (MYMX)

Function

• myoblast-specific protein
• mediates myoblast fusion in formation of multi-nucleated muscle fibers
• role in membrane fusion downstream of the lipid mixing step mediated by MYMK
• acts by generating membrane stresses via its extracellular C-terminus, leading fusion pore formation
• interacts with MYMK, but acts independently of MYMK
• role in skeletal muscle regeneration in response to injury by mediating fusion of satellite cells (muscle stem cells) with injured myofibers

Structure

• AxLyCxL motif is required for myoblast fusion
• belongs to the MYMX family,

Compartment

single-pass cell membrane protein

More general terms

• uncharacterized protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=101929
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:101929
• UniProt: http://www.uniprot.org/uniprot/A0A1B0GTQ4.html