fostemsavir (Rukobia)

Indications

• treatment-resistant HIV1 infection

Dosage

• 600 mg q12 hours

Adverse effects

• nausea (most common)
• elevations in serum transaminases among patients with hepatitis B or hepatitis C
• immune reconstitution syndrome

• drug adverse effects of antiretroviral agents

Mechanism of action

• prodrug of temsavir
• HIV1 glycoprotein 120 (gp120) attachment inhibitor
  • binds directly to the gp120 subunit on the surface of HIV1

More general terms

• antiretroviral agent

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=11319217
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46892186
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46892185
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=76956413