imipenem cilastatin/relebactam (Recarbrio)
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Indications
- complicated urinary tract infection
- complicated intra-abdominal infection
- bacterial pneumonia: hospital-acquired pneumonia & ventilator-associated pneumonia[2][3]
Adverse effects
- diarrhea, nausea, headache, fever, elevated serum transaminases Antibiotic susceptibility:
- Enterobacter cloacae
- Escherichia coli
- Klebsiella aerogenes
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
- Bacteroides caccae
- Bacteroides fragilis
- Bacteroides ovatus,
- Bacteroides stercoris
- Bacteroides thetaiotaomicron
- Bacteroides uniformis
- Bacteroides vulgatus
- Citrobacter freundii
- Enterobacter cloacae
- Escherichia coli
- Fusobacterium nucleatum
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae,
- Parabacteroides distasonis
- Pseudomonas aeruginosa
Drug interactions
- ganciclovir in combination may increase risk of generalized seizures
- Recarbrio may reduce serum level of valproic acid or divalproex
More general terms
Components
References
- ↑ Brown T FDA Approves Drug Trio for UTI, Intra-abdominal Infection. Medscape - Jul 17, 2019. https://www.medscape.com/viewarticle/915723
FDA News Release. July 17, 2019 FDA approves new treatment for complicated urinary tract and complicated intra-abdominal infections [press release]. Rockville, MD. https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatment-complicated-urinary-tract-and-complicated-intra-abdominal-infections - ↑ 2.0 2.1 FDA News Release. June 4, 2020 FDA Approves Antibiotic to Treat Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia. https://www.fda.gov/news-events/press-announcements/fda-approves-antibiotic-treat-hospital-acquired-bacterial-pneumonia-and-ventilator-associated
- ↑ 3.0 3.1 Rapid Review Quiz: Hospital-Acquired Pneumonia Medscape. Sept 15, 2022 https://reference.medscape.com/viewarticle/980567
- ↑ HIGHLIGHTS OF PRESCRIBING INFORMATION imipenem, cilastatin & relebactam (Recarbrio) for injection, intravenous use https://www.merck.com/product/usa/pi_circulars/r/recarbrio/recarbrio_pi.pdf