manganese in specimen

Clinical significance

• chronic inhalation of manganese damages the basal ganglia of the brain, resulting in parkinsonism

Increases

• chemical interferences
  • heparin therapy may contaminate specimen with Mn+2
• clinical disorders
  • acute hepatitis
  • industrial exposure
    • foundry workers
    • welders
    • manufacture of drugs, glass, varnish, feed additives, ceramics
  • myocardial infarction
  • rheumatoid arthritis (erythrocytes)

Decreases

• clinical disorders
  • seizure disorder
  • phenylketonuria

Methods

• atomic absorption spectrometry (AAS)

Notes

• most manganese in blood is bound to hemoglobin in erythrocytes
• manganese is excreted primarily in the feces

More general terms

• special chemistry test

More specific terms

• manganese in blood
• manganese in body fluid
• manganese in erythrocytes
• manganese in hair
• manganese in serum
• manganese in tissue
• manganese in urine
• manganese in water

Additional terms

• manganese [Mn]