manganese in hair

Reference interval

• 0.2-4.4 ug/g (3.6-80.1 nmol/g) dry weight

Clinical significance

• chronic inhalation of manganese damages the basal ganglia of the brain, resulting in parkinsonism

Increases

• chemical interferences
  • heparin therapy may contaminate specimen with Mn+2
• clinical disorders
  • acute hepatitis
  • industrial exposure
    • foundry workers
    • welders
    • manufacture of drugs, glass, varnish, feed additives, ceramics
  • myocardial infarction
  • rheumatoid arthritis (erythrocytes)

Decreases

• clinical disorders
  • seizure disorder
  • phenylketonuria

Methods

• atomic absorption spectrometry (AAS)

Specimen

• cut specimen close to scalp in 2-5 cm lengths
• wash in acetone
• digest in 70% ultrapure nitric acid

More general terms

• manganese in specimen

Additional terms

• manganese [Mn]