manganese in urine

Reference interval

• 0.5-9.8 ug/L (9.1-178 nmol/L)
• toxic range > 10 ug/L (182 nmol/L)

Clinical significance

• chronic inhalation of manganese damages the basal ganglia of the brain, resulting in parkinsonism

Increases

• chemical interferences
  • heparin therapy may contaminate specimen with Mn+2
• clinical disorders
  • acute hepatitis
  • industrial exposure
    • foundry workers
    • welders
    • manufacture of drugs, glass, varnish, feed additives, ceramics
  • myocardial infarction
  • rheumatoid arthritis (erythrocytes)

Decreases

• clinical disorders
  • seizure disorder
  • phenylketonuria

Methods

• atomic absorption spectrometry (AAS)

Specimen

• serum/urine/blood: collect in metal-free container

Notes

• manganese is excreted primarily in the feces

More general terms

• manganese in body fluid
• urine toxicology

More specific terms

• manganese in 24 hour urine

Additional terms

• manganese [Mn]

Component of

• manganese/creatinine in urine