manganese in serum

Reference interval

• 0.59 +/- 0.16 ug/L (10.7 +/- 3.0 nmol/L)
• 0.14 ug/mL

Clinical significance

• chronic inhalation of manganese damages the basal ganglia of the brain, resulting in parkinsonism

Increases

• chemical interferences
  • heparin therapy may contaminate specimen with Mn+2
• clinical disorders
  • acute hepatitis
  • industrial exposure
    • foundry workers
    • welders
    • manufacture of drugs, glass, varnish, feed additives, ceramics
  • myocardial infarction
  • rheumatoid arthritis (erythrocytes)

Decreases

• clinical disorders
  • seizure disorder
  • phenylketonuria

Methods

• atomic absorption spectrometry (AAS)

Specimen

• serum/urine/blood: collect in metal-free container

Notes

• most manganese in blood is bound to hemoglobin in erythrocytes
• manganese is excreted primarily in the feces

More general terms

• manganese in body fluid

Additional terms

• manganese [Mn]