disease interaction(s) of Alzheimer's disease (AD) with depression in the elderly
Jump to navigation
Jump to search
Introduction
Interactions:
- SSRI for depression not beneficial for patients with Alzheimer's disease
Comparative biology
- in mice, inflammation evoked by Abeta oligomers on brain microglia appears to contribute to both depression & dementia[5]
More general terms
References
- ↑ Nelson JC, Devanand DP. A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. J Am Geriatr Soc 2011; 59(issue 4):577-585 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21453380
- ↑ Banerjee S et al Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo- controlled trial The Lancet, Early Online Publication, 18 July 2011 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/21764118 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60830-1/abstract
- ↑ Rosenberg PB, Drye LT, Martin BK et al Sertraline for the treatment of depression in Alzheimer disease. Am J Geriatr Psychiatry. 2010 Feb;18(2):136-45. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20087081
Weintraub D, Rosenberg PB, Drye LT, Sertraline for the treatment of depression in Alzheimer disease: week-24 outcomes. Am J Geriatr Psychiatry. 2010 Apr;18(4):332-40. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20220589 - ↑ Flynn Longmire CV, Drye LT, Frangakis CE et al Is sertraline treatment or depression remission in depressed Alzheimer patients associated with improved caregiver well being? Depression in Alzheimer's Disease Study 2. Am J Geriatr Psychiatry. 2014 Jan;22(1):14-24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24314887 Free PMC Article
- ↑ 5.0 5.1 Ledo JH, Azevedo EP, Beckman D et al. Cross talk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimer's amyloid-beta oligomers in mice. J Neurosci 2016 Nov 30; 36:12106 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27903721