hepatitis B core antibody (HBcAb total) in serum
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Etiology
Clinical significance
- HBcAb total rises with HBcAb IgM, but remains elevated (regardless of whether or not the patient develops chronic hepatitis B)
- HBcAb often remain elevated for life although titers of HBcAb may decline or disappear
- isolated anti-HBc in the absence of HBsAb or HBsAg is common in HIV-infected patients[4]
Management
- antiviral therapy with tenofovir or entecavir
- immunosuppression or immunsuppressive therapy to begin
* > 10 mg prednisone equivalent for 4 weeks
* see hepatitis B infection Management for further details
More general terms
More specific terms
- hepatitis B core antibody (HBcAb total) in serum from donor
- hepatitis B core IgG in serum
- hepatitis B core IgG+IgM in serum
- hepatitis B core IgM (HBcIgM) in serum
Additional terms
Component of
References
- ↑ Laboratory Medicine: Test Selection & Interpretation. Howanitz & Howanitz (eds), Churchill Livingstone, NY, 1991, pg 818-19
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 18. American College of Physicians, Philadelphia 2009, 2012, 2018.
Medical Knowledge Self Assessment Program (MKSAP) 20 American College of Physicians, Philadelphia 2025 - ↑ Hepatitis B Core Antibodies, Total Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0020091.jsp http://ltd.aruplab.com/tests/pub/0020091 https://ltd.aruplab.com/Tests/Pub/0020091
- ↑ Jump up to: 4.0 4.1 Witt MD et al. Predictors of the isolated hepatitis B core antibody pattern in HIV-infected and -uninfected men in the Multicenter AIDS Cohort Study. Clin Infect Dis 2012 Nov 30; PMID: https://www.ncbi.nlm.nih.gov/pubmed/23090927