Figure: indole metabolism
Jump to navigation
Jump to search
Biochemistry
- indole metabolism 1
- enzyme: aromatic amino acid decarboxylase
- substrate: tryptophan
- product: tryptamine + CO2
- indole metabolism 2
- enzyme: monoamine oxidase
- substrate: tryptamine + NADH + H2O + O2
- product: tryptophal + NAD + NH3 + H2O2
- indole metabolism 3
- enzyme: aldehyde oxidoreductase
- substrate: tryptophal
- product: tryptophol
- indole metabolism 4
- enzyme: aldehyde oxidoreductase
- substrate: tryptophal
- product: indoleacetic acid
- indole metabolism 5
- enzyme: aminotransferase
- substrate: tryptophan
- product: indolepyruvate
- indole metabolism 6
- enzyme: carboxy-lyase
- substrate: indolepyruvate
- product: indoleacetic acid + CO2
- indole metabolism 7
- enzyme: tryptophan hydroxylase
- substrate: tryptophan + O2 + NADPH
- product: 5-OH tryptophan + H2O + NADP
- indole metabolism 8
- enzyme: 5-OH tryptophan decarboxylase
- substrate: 5-OH tryptophan
- product: serotonin + CO2
- indole metabolism 9
- enzyme: monoamine oxidase
- substrate: serotonin + NADH + H2O + O2
- product: 5-OH tryptophal + NAD + NH3 + H2O2
- indole metabolism 10
- enzyme: aldehyde oxidoreductase
- substrate: 5-OH tryptophal
- product: 5-OH indoleacetic acid
- indole metabolism 11
- enzyme: alcohol oxidoreductase
- substrate: 5-OH tryptophal
- product: 5-OH tryptophol
- indole metabolism 12
- enzyme: N-methyltransferase
- substrate: serotonin
- product: N'methylserotonin
- indole metabolism 13
- enzyme: acetyltransferase
- substrate: serotonin
- product: N'acetylserotonin
- indole metabolism 14
- enzyme: aminotransferase
- substrate: 5-OH tryptophan
- product: 5-OH indolepyruvate
- indole metabolism 15
- enzyme: carboxy-lyase
- substrate: 5-OH indolepyruvate
- product: 5-OH indoleacetic acid
References
- ↑ Principles of Biochemistry 6th ed., White, Handler, Smith, Hill, & Lehman (eds.) McGraw-Hill, NY 1978, pg 722