tryptophan 5-hydroxylase (tryptophan 5-monooxygenase, TPH1, TPRH, TRPH)

Function

• serotonin biosynthesis, 1st step
• melatonin biosynthesis, 1st step

L-tryptophan + tetrahydrobiopterin + O2
             <-->
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

Cofactor: Fe+2

Structure

• multimer of identical subunits
• belongs to the biopterin-dependent aromatic amino acid hydroxylase family
• contains 1 ACT domain

Alternative splicing

named isoforms=2

Expression

• isoform 2 seems to be less widely expressed than isoform 1

More general terms

• hydroxylase; monooxygenase

Additional terms

• indole metabolism

Database

• UniProt: http://www.uniprot.org/uniprot/P17752.html
• OMIM: https://mirror.omim.org/entry/191060