5-hydroxytryptophan (5-HTP); 2-amino-3-(5-hydroxy)indolylpropionic acid

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Introduction

intermediate between L-tryptophan & 5-hydroxytryptamine (serotonin)

Uses

popular dietary supplement used for

Efficacy[1]: Meta-analysis of published trials as to use of 5-HTP and L-tryptophan in treatment for depression compared to SSRIs and tricyclic antidepressants were inconclusive due to small numbers of sufficiently rigorous studies available.

Although 5-HTP and L-tryptophan may be effective in the treatment of depression, the safety and efficacy of SSRIs and tricyclics have been more thoroughly studied. Dosages for 5-HTP in these trials also varied widely and no consensus for appropriate dosage and frequency of administration was available.

Adverse effects

More general terms

Additional terms

Component of

References

  1. 1.0 1.1 1.2 Cochrane Review, Tryptophan and 5-Hydroxytryptophan for depression. John Wiley, 2004
  2. Das et al. Toxicology Letters 150:111-122, 2004
  3. 3.0 3.1 U. S. Food and Drug Administration. Information Paper on L-tryptophan and 5-hydroxy-L-tryptophan. Feb. 2001 http://vm.cfsan.fda.gov/~dms/ds-tryp1.html

Database