dopa decarboxylase 95-OH tryptophan decarboxylase; aromatic L-amino-acid decarboxylase (DDC, AADC)

Function

• catalyzes decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine L-5-hydroxytryptophan to serotonin L-tryptophan to tryptamine
• catecholamine biosynthesis

Cofactor: pyridoxal phosphate

Structure

• homodimer
• belongs to the group II decarboxylase family

Pathology

• defects in DDC are the cause of aromatic-L-amino-acid decarboxylase deficiency

Pharmacology

• AADC gene therapy investigational treatment of Parkinson's disease

Laboratory

• L-dopa decarboxylase in plasma
• L-dopa decarboxylase in CSF

More general terms

• aromatic amino-acid decarboxylase

Additional terms

• indole metabolism

Database

• UniProt: http://www.uniprot.org/uniprot/P20711.html
• OMIM: https://mirror.omim.org/entry/107930
• OMIM: https://mirror.omim.org/entry/608643
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1644