triad of dyskeratosis congenita (Zinsser-Cole-Engman syndrome)

Etiology

• dyskeratosis congenita

Clinical manifestations

• reticulate hyperpigmentation of skin
• nail dystrophy (longitudinal ridging, splitting & early pterygium formation)
• leukokeratosis of mucous membranes
• other
  • aplastic anemia occurs in 50% of patients
  • ocular anomaly
  • mental retardation
  • short stature
  • premature graying of hair

More general terms

• triad