poly-ADP-ribosylation-amplifying & CtIP-maintaining micropeptide; PAR-amplifying & CtIP-maintaining micropeptide (PACMP)

Function

• micropeptide that acts as a regulator of DNA repair both by preventing KLHL15-mediated ubiquitination & degradation of RBBP8/CtIP, & by promoting the poly-ADP-ribosyltransferase activity of PARP1
• prevents KLHL15-mediated ubiquitination of RBBP8/CtIP by competitively blocking the association between KLHL15 & RBBP8/CtIP
• recruited to DNA damage sites via association with poly-ADP-ribose chains, & enhances the poly-ADP-ribosyltransferase activity of PARP1
• interacts with KLHL15; preventing ubiquitination & degradation of RBBP8/CtIP
• interacts with PARP1

Compartment

• nucleus, nucleolus chromosome

Notes

• recruited to DNA damage sites via interaction with poly-ADP-ribose chains

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/P0DW81.html