plasma factors associated with cognitive function
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Introduction
Plasma contains factors that affect cognitive function
Comparative biology
- plasma beta2 microglobulin (B2M) negatively regulates age-associated cognitive function in hippocampus of mice[3]
increased plasma eotaxin may inhibit learning, memory, & neurogenesis during aging in mice[4]
- age-associated increase in eotaxin in plasma levels in humans & mice[4]
- blood of young mice contains substances that reverse aging processes in heart muscle, skeletal muscle, & brain
- one of these substances is GDF11[1]
References
- ↑ 1.0 1.1 Katsimpardi L et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 2014 May 9; 344:630. (http://dx.doi.org/10.1126/science.1251141) PMID: https://www.ncbi.nlm.nih.gov/pubmed/24797482
Villeda SA et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med 2014 May 4 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24793238 - ↑ Bouchard J, Villeda SA Aging and brain rejuvenation as systemic events J Neurochem. 2015 Jan; 132(1): 5-19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25327899
- ↑ 3.0 3.1 3.2 Smith LK, He Y, Park JS et al beta2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat Med. 2015 Jul 6. doi:http://dx.doi.org/ 10.1038/nm.3898. [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/26147761
- ↑ 4.0 4.1 4.2 Villeda SA et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011 Sep; 477:90 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21886162