cholesterol efflux capacity
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Indications
- assessment of cardiovascular risk (investigational)[1]
Clinical significance
- measures ability of HDL to accept cholesterol from macrophages, a key step in reverse cholesterol transport
- evaluates cholesterol efflux as mediated by ABCA1 (ATP-binding cassette transporter A1)
- provides better estimate of cardiovascular risk than HDL cholesterol or HDL particle size
Specimen
Procedure
- measures the efflux of fluorescence-labeled cholesterol from J774 macrophages to apolipoprotein B-depleted plasma
- the fluorescence-labeled reagent, boron dipyrromethene difluoride (BODIPY) cholesterol is more amenable to use in a large number of samples than radiolabeled cholesterol
More general terms
References
- ↑ 1.0 1.1 Husten L, Fairchild DG, Di Francesco L HDL Function, Not Level, Looks Like the Key Physician's First Watch, Nov 19, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
Rohatgi A et al HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events. N Engl J Med. Nov 18, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25404125 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1409065