LINE-1 retrotransposable element ORF1 protein; L1ORF1p; LINE retrotransposable element 1; LINE1 retrotransposable element 1 (L1RE1, LRE1)

Function

• nucleic acid-binding protein
• essential for retrotransposition of LINE-1 elements in the genome
• may function as a nucleic acid chaperone binding its own transcript thus preferentially mobilizing the transcript from which it is encoded
• identified with its own transcript in a cytoplasmic ribonucleoprotein complex
• homotrimer (via coiled coil domain)
• may also form larger homooligomers
• may interact with DDX39A, HNRNPA1, SERBP1 & YBX1

Structure

• the coiled coil domain mediates homotrimerization
• the RRM & the CTD domain are both required for proper RNA-binding activity
• belongs to the transposase 22 family

Compartment

• cytoplasm. nucleus, nucleolus
• mainly cytoplasmic where it is enriched in stress granules
• also more rarely detected in the nucleolus

More general terms

• uncharacterized protein

Database

• OMIM: https://mirror.omim.org/entry/151626
• UniProt: http://www.uniprot.org/uniprot/Q9UN81.html