ATP-dependent RNA helicase DDX39A; DEAD box protein 39; nuclear RNA helicase URH49 (DDX39A, DDX39)

Function

• role in pre-mRNA splicing
• required for the export of mRNA out of the nucleus
• binds THOC4 & DDX39B/BAT1
• interacts with SARNP

Structure

• belongs to the DEAD box helicase family, DECD subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

nucleus (putative)

Expression

• detected in testis > brain, kidney, lung, thymus, spleen & salivary gland
• up-regulated in proliferating cells
• present at low levels in quiescent cells

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10212
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10212
• UniProt: http://www.uniprot.org/uniprot/O00148.html