degradation of A4

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Introduction

Degradation of A4:

alpha-2 macroglobulin may participate in clearance & degradation of A4[2][3]. LRP binds to & internalizes A4-associated alpha-2 macroglobulin, attenuating neurotoxicity of A4. It is also of interest that apo E binds to LRP. Does LRP bind & internalize A4-associated apo E as well?

References

  1. Selkoe DJ. Clearing the brain's amyloid cobwebs. Neuron. 2001 Oct 25;32(2):177-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11683988
  2. 2.0 2.1 Maccioni RB et al The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Arch Med Res. 2001 Sep-Oct;32(5):367-81. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11578751
  3. 3.0 3.1 Fabrizi C, Businaro R, Lauro GM, Fumagalli L. Role of alpha2-macroglobulin in regulating amyloid beta-protein neurotoxicity: protective or detrimental factor? J Neurochem. 2001 Jul;78(2):406-12. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11461976