high molecular weight kininogen in plasma (Fitzgerald factor assay)

Indications

• workup of coagulation disorder

Clinical significance

• routine prolonged PTT evaluation finds no explanation
• PTT is normal in the mixing study
• factor VIII, factor IX, factor XI, & factor XII are normal
• prothrombin time & plasma fibrinogen are normal
• lupus anticoagulant assays are negative
• if prekallikrein assays are normal, HMW kininogen assays may be considered

More general terms

• clinical coagulation test

Additional terms

• high molecular weight [HMW] kininogen; alpha-2 thiol proteinase inhibitor (KNG1)
• low molecular weight kininogen in plasma