high molecular weight [HMW] kininogen; alpha-2 thiol proteinase inhibitor (KNG1)

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Introduction

Normally exists in plasma in a 1:1 complex with prekallikrein. HMW kininogen supports reciprocal activation of factor XII, factor XI & prekallikrein.

More general terms

Additional terms

References

  1. Andrews BS. Is the WKS motif the tissue-factor binding site for coagulation factor VII? Trends Biochem Sci. 1991 Jan;16(1):31-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053135
  2. Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999

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