apoptosis-inducing factor 2; apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; p53-responsive gene 3 protein (AIFM2, AMID, PRG3)

Function

• oxidoreductase
• play a role in mediating a p53/TP53-dependent, caspase- independent apoptosis
• probable oxidoreductase
• binds to DNA (sequence-independent)
• may contribute to genotoxin-induced growth arrest

Cofactor:

• FAD
• binds 6-hydroxy-FAD non-covalently

Structure

• belongs to the FAD-dependent oxidoreductase family

Compartment

cytoplasm. mitochondrion outer membrane

Alternative splicing

• named isoforms=2
• detected in most normal tissues as two transcripts of 1.8 & 4.0 kb

Expression

• highly expressed in heart
• moderately expressed in liver & skeletal muscles
• not expressed at low levels in placenta, lung, kidney, & pancreas
• both transcripts expressed following p53/TP53 induction
• detected at 4 hours after induction by p53/TP53

Pathology

• down-regulated in a wide range of human tumors
• the shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells

More general terms

• myristoylated protein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84883
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84883
• OMIM: https://mirror.omim.org/entry/605159
• UniProt: http://www.uniprot.org/uniprot/Q9BRQ8.html