tripartite motif-containing protein 66 (TRIM66, C11orf29, KIAA0298)

Function

• may function as transcription repressor
  • repressive effects are mediated, at least in part, by recruitment of deacetylase activity
• may play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation & centromere association (putative)
• can form homo- & heterodimers
• interacts with CBX5, CBX1 & CBX3 via PxVxL motif (putative)

Structure

• contains 2 B box-type Zn+2 fingers
• contains 1 bromo domain
• contains 1 PHD-type Zn+2 finger

Compartment

• nucleus
• forms discrete foci within the centromeric chromocenter & surrounding nucleoplasm

Alternative splicing

named isoforms=2

More general terms

• nuclear protein
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9866
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9866
• OMIM: https://mirror.omim.org/entry/612000
• UniProt: http://www.uniprot.org/uniprot/O15016.html