agomelatine (Valdoxan, Melitor, Thymanax)

Introduction

Used in Europe with restrictions. Not FDA-approved in US.

Indications

• depression

Adverse effects

• negative sexual effects
• discontinuation effects
• hepatotoxicity a cause for Novartis withdraw effort for FDA approval in US

• drug adverse effects of antidepressants
• drug adverse effects of psychotropic agents

Drug interactions

• a cause for Novartis to withdraw effort for FDA approval in US

• drug interaction(s) of benzodiazepines with antidepressants
• drug interaction(s) of antidepressants with benzodiazepines
• drug interaction(s) of NSAIDs with antidepressants

Mechanism of action

• melatonin receptor agonist

More general terms

• antidepressant

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=82148