hydroxyproline in body fluid

Indications

• assessment bone resorption (urine)
  • acromegaly
  • hyperthyroidism
  • hyperparathyroidism
  • Paget's disease of bone
  • rickets, osteomalacia
  • bone fracture
  • bony metastases
  • osteoporosis
  • sarcoidosis
  • severe burns
  • acute osteomyelitis
  • congenital hypophosphatasia
  • fibrous dysplasia
  • growth spurts

Reference interval

• adult male: 9-73 mg/day (urine)
• adult female: 7-49 mg/day

Clinical significance

• measure of collagen turnover (urine)

Increases

• acromegaly
• hyperthyroidism
• hyperparathyroidism
• Paget's disease of bone
• rickets, osteomalacia
• bone fracture
• bony metastases
• osteoporosis
• sarcoidosis
• severe burns
• acute osteomyelitis
• congenital hypophosphatasia
• fibrous dysplasia
• growth spurts

Decreases

• hypopituitarism
• hypothyroidism
• hypoparathyroidism
• malnutrition
• muscular dystrophy

More general terms

• general chemistry test

More specific terms

• hydroxyproline in amniotic fluid
• hydroxyproline in blood
• hydroxyproline in CSF
• hydroxyproline in urine
• hydroxyproline in vitreous fluid

Additional terms

• 4-hydroxyproline