protein Plunc; palate lung & nasal epithelium clone protein; lung-specific protein X; nasopharyngeal carcinoma-related protein; tracheal epithelium-enriched protein; secretory protein in upper respiratory tracts; von Ebner protein Hl (PLUNC, BPIFA1, LUNX, NASG, SPURT, UNQ787/PRO1606)
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Function
- role in innate immune responses of the upper airways
- role in airway inflammatory response after exposure to irritants (putative)
- binds lipopolysaccharides
Structure
- belongs to the BPI/LBP/Plunc superfamily, Plunc family
- N-glycosylated (putative)
Compartment
- secreted
- found in nasal mucus
- pical side of airway epithelial cells
Expression
- lung, upper airways & nasopharyngeal regions, including trachea & nasal epithelium
- specifically expressed in secretory ducts & submucosal glands of tracheobronchial tissues
- highest expression in trachea & progressive decrease from proximal (bronchial) to distal (bronchiolar) airways
- induced by all-trans retinoic acid (ATRA)
Pathology
- expressed in lung cancers & some other types of cancer
- associated with tumor progression (putative)